Chronic Hepatitis B with Fanconi’s Syndrome Triggered by Short-term Administration of Adefovir Dipivoxil
نویسندگان
چکیده
منابع مشابه
A randomized, multi-central, controlled study of patients with hepatitis B e antigen-positive chronic hepatitis B treated by adefovir dipivoxil or adefovir dipivoxil plus bicyclol
OBJECTIVE To evaluate the efficacy and safety profiles of patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) treated with adefovir dipivoxil (ADV) or ADV plus bicyclol, and to optimize the treatment strategy for CHB patients. PATIENTS AND METHODS A total of 250 patients with HBeAg-positive CHB were randomized to ADV plus bicyclol combination group and ADV monothera...
متن کاملThe Efficacy of L-Carnitine for Fanconi’s Syndrome caused by Long-Term Administration of Adefovir Dipivoxil(Adv) in a Patient with Chronic Hepatitis B: A Case Report
An estimated 400 million people worldwide are chronically infected with Hepatitis B Virus (HBV) [1]. HBV-infected patients may develop cirrhosis and hepatocellular carcinoma [2]. Thus, the aims of HBV treatments are to achieve suppression of HBV replication and cause remission of chronic liver disease. Pegylated interferon and oral nucleoside analogues are the main therapeutic agents that have ...
متن کاملAdefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
BACKGROUND In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains. METHODS We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10 mg of adefovir dipivoxil (172 patients), 30 mg of adefovir dipivoxil (173), or placebo (170) d...
متن کاملLong-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B.
BACKGROUND Large clinical studies assessing long-term adefovir dipivoxil salvage monotherapy in patients with lamivudine-resistant chronic hepatitis B (CHB) are lacking, particularly in patients positive for hepatitis B e antigen (HBeAg). We assessed the efficacy and resistance profile of adefovir dipivoxil monotherapy for up to 5 years in a large cohort of Korean patients with lamivudine-resis...
متن کاملRelationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B
BACKGROUND To assess the relationship between adefovir dipivoxil and renal function after anti-hepatitis B virus therapy and elucidate the risk factors involved. METHODS Based on the requirements of the Cochrane systematic review methodology, 21 observational articles on adefovir dipivoxil-associated renal dysfunction were obtained by searching various databases, between January 1, 1995 and J...
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ژورنال
عنوان ژورنال: Journal of St. Marianna University
سال: 2015
ISSN: 2185-1336,2189-0277
DOI: 10.17264/stmarieng.6.71